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Best OTC for constipation relief — it’s a question millions of Indians quietly Google every day. Whether it’s the result of travel, stress, diet changes, or certain medications, constipation can be both uncomfortable and frustrating. The good news? You don’t always need a prescription or harsh laxatives to feel better.
In this guide, we’ll explore the safest, most effective over-the-counter (OTC) constipation treatments, backed by science and trusted by pharmacists. You’ll also learn natural ways to prevent constipation so relief becomes the last thing you need.
When it comes to safety, osmotic laxatives like Polyethylene Glycol (PEG 3350)—sold under names like PEGLEC, ClearLax, and Miralax—are considered the best OTC option.
Here’s why doctors and pharmacists prefer it:
💊 How to use:
Dissolve one sachet (usually 17 g) in a full glass of water once daily. It may take 1–3 days for results—so don’t expect overnight magic.
🔗 Source: Harvard Health – How to Treat Constipation Safely

While PEG 3350 is the safest first-line option, you might encounter other types in pharmacies. Here’s how they compare:
Pharmacists often say: “Prevention is the best laxative.”
Here’s how to keep your digestion happy naturally:
These habits not only prevent constipation but also improve overall digestive health.

Before starting any OTC remedy:
When it comes to the best OTC for constipation relief, Polyethylene Glycol (PEG 3350) stands out as the safest, non-habit-forming choice. Pair it with good hydration, fiber, and movement—and you’ll rarely need a laxative again.
Constipation doesn’t have to control your comfort. Treat it gently, wisely, and naturally.
Also Read: Diabetes Care 30-Day Challenge: Transform Your Sugar Control Naturally
The safest and most effective OTC option is Polyethylene Glycol (PEG 3350), an osmotic laxative available in India as PEGLEC or ClearLax.
Yes, it’s considered safe for daily use for short to medium durations. Always consult your doctor for long-term use.
Stimulant laxatives like Bisacodyl act faster (6–10 hours) but should be used occasionally.
Yes, when taken with adequate water, Isabgol is a natural and safe fiber supplement.
Morning is best, especially after breakfast, to align with your body’s natural rhythm.